Basic Information
ID: ALA4323207
Type: Binding
Description: Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level by measuring log ratio of protein level before and after treatment at 0.1 uM measured after 3 hrs relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: Cereblon/GSPT1/Cullin-4A/DDB1(ALA4524003)
Document: ALA4321819
Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level by measuring log ratio of protein level before and after treatment at 0.1 uM measured after 3 hrs relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4323207
log2FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 774.72 | 6.07 | 6.07 |