Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein ...

Basic Information

ID: ALA4323254

Type: Binding

Description: Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level at 1 to 3 uM after 24 hrs by Western blot analysis

Format: BAO_0000219

Organism: Homo sapiens

Target:  Cereblon/GSPT1/Cullin-4A/DDB1(ALA4524003)

Document:  ALA4321819

Protac activity at GSPT1/CUL4/DDB1/CRBN in human RS4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as decrease in GSPT1 protein level at 1 to 3 uM after 24 hrs by Western blot analysis: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
704.595.185.18
746.675.295.29