Basic Information
ID: ALA4324029
Type: Binding
Description: Competitive inhibition of human topoisomerase 2alpha ATPase activity assessed as Km for ATP hydrolysis with DNA relaxation at 20 uM using supercoiled plasmid DNA as susbtrate after 1 hr by malachite green assay/Michelis-Menten kinetics analysis (Rvb = 317.8 to 350.1 microM)
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA topoisomerase II alpha(ALA1806)
Document: ALA4321838
Competitive inhibition of human topoisomerase 2alpha ATPase activity assessed as Km for ATP hydrolysis with DNA relaxation at 20 uM using supercoiled plasmid DNA as susbtrate after 1 hr by malachite green assay/Michelis-Menten kinetics analysis (Rvb = 317.8 to 350.1 microM): 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4324029
Km
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 313.32 | 2.69 | 2.69 |
| 312.30 | 3.41 | 3.41 |