Basic Information
ID: ALA4324037
Type: Binding
Description: Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal transition by measuring reduction in vimentin expression at 10 uM after 72 hrs by Hoechst 33342 staining based GFP reporter gene assay
Format: BAO_0000019
Organism: Homo sapiens
Target: DNA topoisomerase II alpha(ALA1806)
Document: ALA4321838
Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal transition by measuring reduction in vimentin expression at 10 uM after 72 hrs by Hoechst 33342 staining based GFP reporter gene assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4324037
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 427.46 | 4.83 | 4.83 |
| 312.30 | 3.41 | 3.41 |