Basic Information
ID: ALA4324041
Type: Binding
Description: Inhibition of human topoisomerase 2alpha mediated decatenation at 30 uM using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP addition and measured after 1 hr by ethidium bromide staining based gel electrophoresis method relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA topoisomerase II alpha(ALA1806)
Document: ALA4321838
Inhibition of human topoisomerase 2alpha mediated decatenation at 30 uM using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP addition and measured after 1 hr by ethidium bromide staining based gel electrophoresis method relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4324041
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 326.33 | 3.71 | 3.71 |
| 397.41 | 2.72 | 2.72 |
| 334.40 | 4.78 | 4.78 |
| 280.29 | 2.36 | 2.36 |
| 335.36 | 3.52 | 3.52 |
| 354.38 | 4.44 | 4.44 |
| 403.44 | 3.62 | 3.62 |
| 278.31 | 3.57 | 3.57 |
| 427.46 | 4.83 | 4.83 |
| 328.75 | 3.92 | 3.92 |
| 434.50 | 3.23 | 3.23 |
| 335.36 | 3.52 | 3.52 |
| 318.33 | 4.31 | 4.31 |
| 335.36 | 3.52 | 3.52 |
| 296.30 | 3.70 | 3.70 |
| 417.47 | 4.01 | 4.01 |
| 312.30 | 3.41 | 3.41 |
| 320.39 | 4.59 | 4.59 |
| 411.43 | 3.11 | 3.11 |
| 340.35 | 4.02 | 4.02 |
| 284.34 | 3.63 | 3.63 |
| 346.31 | 4.58 | 4.58 |
| 346.31 | 4.58 | 4.58 |
| 284.34 | 3.63 | 3.63 |
| 441.49 | 5.13 | 5.13 |
| 362.31 | 4.29 | 4.29 |
| 296.30 | 3.70 | 3.70 |
| 268.27 | 3.16 | 3.16 |
| 294.31 | 3.27 | 3.27 |
| 268.27 | 3.16 | 3.16 |