Basic Information
ID: ALA4324333
Type: Functional
Description: Antitumor activity against human A549 cells harboring KRAS G12C mutant xenografted in athymic Nude-Foxn1nu mouse assessed as tumor regression at 25 mg/kg, po bid adminstered for 21 days and measured twice per week in presence of selumetinib by caliper method relative to control
Format: BAO_0000218
Organism: Homo sapiens
Cell type: A549
Target: A549(ALA392)
Document: ALA4321846
Antitumor activity against human A549 cells harboring KRAS G12C mutant xenografted in athymic Nude-Foxn1nu mouse assessed as tumor regression at 25 mg/kg, po bid adminstered for 21 days and measured twice per week in presence of selumetinib by caliper method relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4324333
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 494.51 | 3.07 | 3.07 |