Basic Information
ID: ALA4324540
Type: Binding
Description: Corrector activity at CFTR F508del mutant (unknown origin) transfected in human HEK293 membrane cells assessed as increase in CFTR level at 3 uM incubated for 24 hrs in presence of VX-809 by using pHTomato probe based fluorescence inverted microscopic analysis relative to VX-809 alone
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Cystic fibrosis transmembrane conductance regulator(ALA4051)
Document: ALA4321853
Corrector activity at CFTR F508del mutant (unknown origin) transfected in human HEK293 membrane cells assessed as increase in CFTR level at 3 uM incubated for 24 hrs in presence of VX-809 by using pHTomato probe based fluorescence inverted microscopic analysis relative to VX-809 alone: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4324540
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 422.62 | 4.69 | 4.69 |
| 458.61 | 4.89 | 4.89 |