Basic Information
ID: ALA4324622
Type: Binding
Description: Protac activity against VHL/MEK1/2 in human HT-29 cells harboring with BRAF V600E variant assessed as phosphorylation of MEK at S218/222 residues at 0.3 uM pretreated with VHL ligand, VH 032 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis
Organism: Homo sapiens
Cell type: HT-29
Activity Charts
Bioactivity
Activity Types for Assay ALA4324622
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 1076.08 |