Basic Information
ID: ALA4324641
Type: Binding
Description: Protac activity against VHL/MEK1/2 in human SK-MEL-28 cells harboring with BRAF V600E variant assessed as phosphorylation of ERK at T202/Y204 residues at 0.3 uM pretreated with NEDD8-activating enzyme inhibitor, MLN4924 for 2 hrs followed by incubation with compound for 10 hrs by Western blot analysis
Organism: Homo sapiens
Cell type: SK-MEL-28
Activity Charts
Bioactivity
Activity Types for Assay ALA4324641
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 1076.08 |