Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as AR degradation at 100 nM preincubated with AR antagonist N-((1r,3r)-3-(3-C...

ID: ALA4325015

Type: Binding

Description: Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as AR degradation at 100 nM preincubated with AR antagonist N-((1r,3r)-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxamide for 2 hrs followed by incubation with compound addition for 6 hrs by Western blot analysis

Format: BAO_0000219

Organism: Homo sapiens

Cell type: LNCaP

Target:  VHL/Androgen receptor(ALA4523730)

Document:  ALA4321866

Protac activity against VHL/AR in AR-positive human LNCAP cells assessed as AR degradation at 100 nM preincubated with AR antagonist N-((1r,3r)-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxamide for 2 hrs followed by incubation with compound addition for 6 hrs by Western blot analysis: 1