Assay Report Card

Basic Information

ID: ALA4325327

Type: Binding

Description: Inhibition of N-terminal GST-tagged human ROCK1 catalytic domain (1 to 477 residues) expressed in baculovirus expression system using biotin-STK-substrate 2 as substrate preincubated with enzyme for 5 mins followed by ATP addition and measured after 2 hrs by TR-FRET assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4325327

IC50

Total(17)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
315.40	2.28	2.28
341.44	2.84	2.84
386.31	1.89	1.89
388.32	2.50	2.50
374.30	2.11	2.11
287.35	1.72	1.72
388.32	2.35	2.35
363.87	2.42	2.42
329.43	2.89	2.89
388.32	2.28	2.28
386.31	2.27	2.27
329.43	2.89	2.89
388.32	2.35	2.35
405.83	3.21	3.21
341.44	2.84	2.84
388.32	2.50	2.50
388.32	2.45	2.45