Basic Information
ID: ALA4327371
Type: Binding
Description: Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in HEK293F cells pretreated for 15 mins followed by substrate and [3H]-SAM addition measured after 60 mins by scintillation proximity assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4327371
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 384.42 | -1.44 | -1.44 |
| 298.36 | 3.21 | 3.21 |
| 280.37 | 3.07 | 3.07 |
| 324.38 | 2.47 | 2.47 |
| 294.40 | 3.38 | 3.38 |
| 383.45 | 0.44 | 0.44 |
| 372.47 | 4.87 | 4.87 |
| 331.42 | 3.62 | 3.62 |
| 322.41 | 3.28 | 3.28 |
| 305.38 | 2.95 | 2.95 |
| 339.40 | 3.29 | 3.29 |
| 294.40 | 3.38 | 3.38 |
| 364.37 | 3.97 | 3.97 |
| 374.39 | 3.14 | 3.14 |
| 314.82 | 3.73 | 3.73 |
| 338.41 | 2.86 | 2.86 |
| 384.28 | 3.71 | 3.71 |
| 330.43 | 4.23 | 4.23 |
| 352.43 | 3.25 | 3.25 |
| 350.34 | 2.88 | 2.88 |
| 359.27 | 3.84 | 3.84 |
| 323.40 | 1.90 | 1.90 |
| 339.40 | 3.29 | 3.29 |
| 310.40 | 3.08 | 3.08 |
| 352.43 | 3.25 | 3.25 |