Basic Information
ID: ALA4327486
Type: Binding
Description: Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM addition measured after 30 mins by spectrofluorimetric method
Format: BAO_0000219
Organism: Homo sapiens
Cell type: MDCK
Target: P-glycoprotein 1(ALA4302)
Document: ALA4325869
Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM addition measured after 30 mins by spectrofluorimetric method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4327486
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 393.53 | 4.88 | 4.88 |
| 349.43 | 3.85 | 3.85 |
| 409.48 | 3.86 | 3.86 |
| 485.58 | 5.56 | 5.56 |
| 485.58 | 5.69 | 5.69 |
| 473.57 | 5.57 | 5.57 |
| 499.61 | 5.61 | 5.61 |
| 465.59 | 5.42 | 5.42 |
| 471.98 | 5.38 | 5.38 |
| 485.58 | 5.56 | 5.56 |
| 516.43 | 5.49 | 5.49 |
| 377.48 | 4.63 | 4.63 |
| 437.54 | 4.64 | 4.64 |
| 391.51 | 5.02 | 5.02 |
| 485.58 | 5.56 | 5.56 |
| 457.53 | 4.95 | 4.95 |
| 435.52 | 4.42 | 4.42 |
| 457.95 | 4.99 | 4.99 |
| 499.61 | 6.08 | 6.08 |
| 423.51 | 4.25 | 4.25 |
| 513.63 | 6.39 | 6.39 |
| 363.46 | 4.24 | 4.24 |
| 451.56 | 5.03 | 5.03 |