Basic Information
ID: ALA4328854
Type: Binding
Description: Inhibition of human chymotrypsin-like activity of 20S constitutive proteasome using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Proteasome Macropain subunit MB1(ALA4662)
Document: ALA4325885
Inhibition of human chymotrypsin-like activity of 20S constitutive proteasome using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4328854
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 719.92 | 2.58 | 2.58 |
| 394.48 | 3.90 | 3.90 |
| 398.50 | 3.90 | 3.90 |
| 446.57 | 3.30 | 3.30 |
| 342.40 | 2.04 | 2.04 |
| 370.45 | 2.68 | 2.68 |
| 394.39 | 3.96 | 3.96 |
| 356.43 | 2.29 | 2.29 |
| 418.54 | 5.05 | 5.05 |
| 407.27 | 2.49 | 2.49 |
| 436.47 | 4.91 | 4.91 |
| 400.44 | 1.45 | 1.45 |
| 358.40 | 1.74 | 1.74 |
| 369.46 | 3.29 | 3.29 |
| 372.43 | 1.27 | 1.27 |
| 370.45 | 2.68 | 2.68 |
| 455.58 | 4.51 | 4.51 |
| 370.45 | 2.68 | 2.68 |
| 428.53 | 3.91 | 3.91 |
| 398.50 | 3.90 | 3.90 |
| 372.43 | 2.13 | 2.13 |
| 369.46 | 3.29 | 3.29 |
| 398.50 | 3.90 | 3.90 |
| 398.51 | 3.46 | 3.46 |
| 369.46 | 3.29 | 3.29 |
| 359.43 | 2.88 | 2.88 |
| 376.48 | 2.75 | 2.75 |
| 393.49 | 3.77 | 3.77 |
| 384.48 | 2.93 | 2.93 |
| 386.47 | 4.03 | 4.03 |
| 384.48 | 3.07 | 3.07 |