Basic Information
ID: ALA4329825
Type: Binding
Description: Inhibition of P-gp-mediated doxorubicin efflux in human Lucena 1 cells assessed as ratio of doxorubicin fluorescence intensity in presence of compound to doxorubicin fluorescence intensity in absence of compound at 25 uM preincubated for 1 hr followed by doxorubicin addition measured after 1 hr by flow cytometry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4329825
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 268.36 | 4.83 | 4.83 |
| 454.61 | 5.09 | 5.09 |
| 371.52 | 6.00 | 6.00 |
| 239.27 | 3.55 | 3.55 |
| 1202.63 | ||
| 296.41 | 5.43 | 5.43 |
| 255.27 | 3.26 | 3.26 |
| 299.33 | 2.93 | 2.93 |
| 269.30 | 3.27 | 3.27 |
| 297.35 | 4.17 | 4.17 |
| 440.54 | 5.30 | 5.30 |
| 468.59 | 6.08 | 6.08 |
| 496.64 | 6.86 | 6.86 |
| 356.46 | 4.16 | 4.16 |
| 384.52 | 4.94 | 4.94 |
| 412.57 | 5.72 | 5.72 |
| 560.55 | 3.81 | 3.81 |
| 556.61 | 4.73 | 4.73 |
| 379.42 | 3.38 | 3.38 |
| 584.66 | 5.51 | 5.51 |
| 440.45 | 3.91 | 3.91 |
| 355.42 | 3.83 | 3.83 |