Basic Information
ID: ALA4331432
Type: Binding
Description: Inhibition of human GST-tagged BRAF V600E mutant (416 to 766 residues) using human full length 6His-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by filter binding method
Format: BAO_0000357
Organism: Homo sapiens
Target: Serine/threonine-protein kinase B-raf(ALA5145)
Document: ALA4330078
Inhibition of human GST-tagged BRAF V600E mutant (416 to 766 residues) using human full length 6His-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by filter binding method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4331432
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 464.83 | 5.55 | 5.55 |
| 489.93 | 5.54 | 5.54 |
| 424.52 | 5.05 | 5.05 |
| 606.65 | 5.93 | 5.93 |
| 445.91 | 4.84 | 4.84 |
| 513.91 | 5.86 | 5.86 |
| 622.65 | 5.31 | 5.31 |
| 515.92 | 6.11 | 6.11 |
| 429.46 | 4.33 | 4.33 |
| 577.61 | 4.96 | 4.96 |
| 608.66 | 6.17 | 6.17 |
| 513.91 | 5.86 | 5.86 |
| 411.47 | 4.19 | 4.19 |
| 445.91 | 4.84 | 4.84 |
| 564.57 | 5.04 | 5.04 |
| 528.92 | 6.25 | 6.25 |
| 592.62 | 5.68 | 5.68 |
| 429.46 | 4.33 | 4.33 |