Basic Information
ID: ALA4333226
Type: Binding
Description: Inhibition of PFKFB3 in human HCT116 cell lysates assessed as reduction in glycolytic-flux induced fructose-2,6-bisphosphate formation using fructose-6-phosphate as substrate treated with cells prior to glucose stimulation followed by PFK1 and substrate addition and measured at 0.5 mins interval for 45 mins
Format: BAO_0000220
Organism: Homo sapiens
Subcellular Fraction: Lysate
Target: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(ALA2331053)
Document: ALA4330130
Inhibition of PFKFB3 in human HCT116 cell lysates assessed as reduction in glycolytic-flux induced fructose-2,6-bisphosphate formation using fructose-6-phosphate as substrate treated with cells prior to glucose stimulation followed by PFK1 and substrate addition and measured at 0.5 mins interval for 45 mins: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4333226
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 463.55 | 3.97 | 3.97 |
| 496.60 | 4.06 | 4.06 |
| 491.60 | 4.61 | 4.61 |
| 494.62 | 5.39 | 5.39 |
| 505.58 | 4.28 | 4.28 |
| 491.56 | 3.89 | 3.89 |
| 526.67 | 4.76 | 4.76 |
| 457.56 | 4.78 | 4.78 |
| 535.63 | 5.14 | 5.14 |
| 505.58 | 4.28 | 4.28 |
| 394.44 | 4.03 | 4.03 |
| 493.57 | 3.65 | 3.65 |
| 519.61 | 4.67 | 4.67 |
| 486.54 | 4.65 | 4.65 |
| 519.61 | 4.67 | 4.67 |
| 474.53 | 4.91 | 4.91 |
| 422.49 | 4.63 | 4.63 |
| 535.61 | 3.90 | 3.90 |
| 472.51 | 4.97 | 4.97 |
| 408.47 | 4.29 | 4.29 |
| 477.57 | 4.36 | 4.36 |
| 491.60 | 4.75 | 4.75 |
| 527.65 | 5.24 | 5.24 |
| 443.53 | 4.44 | 4.44 |
| 488.56 | 4.59 | 4.59 |
| 512.64 | 4.51 | 4.51 |
| 523.62 | 4.74 | 4.74 |
| 491.60 | 4.75 | 4.75 |
| 495.56 | 4.50 | 4.50 |
| 429.51 | 4.18 | 4.18 |
| 505.58 | 4.14 | 4.14 |
| 521.61 | 4.80 | 4.80 |
| 428.52 | 4.94 | 4.94 |
| 507.58 | 5.12 | 5.12 |
| 499.60 | 4.55 | 4.55 |
| 491.56 | 3.94 | 3.94 |
| 491.60 | 4.70 | 4.70 |
| 505.58 | 4.28 | 4.28 |
| 526.67 | 4.90 | 4.90 |
| 494.62 | 5.39 | 5.39 |