Basic Information
ID: ALA4337962
Type: Binding
Description: Inhibition of human GLS1 expressed in Escherichia coli strain BL21 (DE3)pLysS pre-incubated for 10 mins before glutamine addition and measured after 60 mins by bovine liver glutamate dehydrogenase based coupled enzyme assay
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Liver
Target: Glutaminase kidney isoform, mitochondrial(ALA2146302)
Document: ALA4334507
Inhibition of human GLS1 expressed in Escherichia coli strain BL21 (DE3)pLysS pre-incubated for 10 mins before glutamine addition and measured after 60 mins by bovine liver glutamate dehydrogenase based coupled enzyme assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4337962
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 524.70 | 4.27 | 4.27 |
| 571.59 | 4.55 | 4.55 |
| 647.79 | 4.36 | 4.36 |
| 617.76 | 4.36 | 4.36 |
| 622.18 | 5.00 | 5.00 |
| 650.69 | 4.70 | 4.70 |
| 642.75 | 3.70 | 3.70 |
| 615.79 | 4.96 | 4.96 |
| 601.76 | 4.66 | 4.66 |
| 610.75 | 4.30 | 4.30 |
| 666.69 | 4.58 | 4.58 |
| 666.63 | 5.11 | 5.11 |
| 615.79 | 4.96 | 4.96 |
| 610.75 | 4.30 | 4.30 |
| 612.72 | 3.69 | 3.69 |
| 587.74 | 4.35 | 4.35 |
| 596.72 | 3.99 | 3.99 |
| 632.73 | 4.26 | 4.26 |
| 612.75 | 4.22 | 4.22 |
| 605.73 | 4.49 | 4.49 |