Basic Information
ID: ALA4338548
Type: Binding
Description: Inhibition of class 1 HDAC in human Cal27CisR cells assessed as potentiation of cisplatin-induced apoptosis assessed as increase in caspase-3/7 activation at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and measured after 24 hrs by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based imaging analysis relative to cisplatin
Format: BAO_0000219
Organism: Homo sapiens
Target: Class 1 histone deacetylase(ALA4523988)
Document: ALA4334526
Inhibition of class 1 HDAC in human Cal27CisR cells assessed as potentiation of cisplatin-induced apoptosis assessed as increase in caspase-3/7 activation at 0.5 uM preincubated for 48 hrs followed by cisplatin addition and measured after 24 hrs by CellEvent caspase 3/7 green detection reagent/Hoechst 33342 staining based imaging analysis relative to cisplatin: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4338548
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 535.65 | 4.55 | 4.55 |