Basic Information
ID: ALA4338899
Type: Binding
Description: Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of biotin-labelled SRC-1 peptide recruitment preincubated for 15 mins followed by biotin-labelled SRC-1 peptide addition and measured after overnight incubation by TR-FRET assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Nuclear receptor ROR-gamma(ALA1741186)
Document: ALA4334546
Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of biotin-labelled SRC-1 peptide recruitment preincubated for 15 mins followed by biotin-labelled SRC-1 peptide addition and measured after overnight incubation by TR-FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4338899
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 411.24 | 5.40 | 5.40 |
| 478.79 | 5.61 | 5.61 |
| 463.77 | 5.30 | 5.30 |
| 444.80 | 5.76 | 5.76 |
| 457.89 | 3.67 | 3.67 |
| 485.82 | 3.81 | 3.81 |
| 480.78 | 6.04 | 6.04 |
| 463.77 | 5.30 | 5.30 |
| 477.80 | 5.48 | 5.48 |
| 497.23 | 6.55 | 6.55 |
| 397.26 | 5.76 | 5.76 |
| 449.82 | 5.06 | 5.06 |
| 480.78 | 6.04 | 6.04 |
| 452.82 | 4.09 | 4.09 |
| 464.76 | 4.69 | 4.69 |
| 492.81 | 5.91 | 5.91 |
| 434.88 | 5.53 | 5.53 |
| 462.79 | 5.90 | 5.90 |
| 485.82 | 3.81 | 3.81 |
| 466.82 | 5.80 | 5.80 |
| 447.30 | 4.95 | 4.95 |
| 497.23 | 6.55 | 6.55 |
| 469.82 | 4.84 | 4.84 |
| 462.79 | 5.90 | 5.90 |
| 485.82 | 3.81 | 3.81 |