Basic Information
ID: ALA4339649
Type: Binding
Description: Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4339649
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 319.82 | 3.51 | 3.51 |
| 311.36 | 3.24 | 3.24 |
| 348.33 | 3.21 | 3.21 |
| 323.37 | 3.38 | 3.38 |
| 341.36 | 3.33 | 3.33 |
| 310.37 | 4.19 | 4.19 |
| 313.79 | 3.44 | 3.44 |
| 327.82 | 3.75 | 3.75 |
| 376.34 | 2.69 | 2.69 |
| 348.33 | 3.21 | 3.21 |
| 347.34 | 3.81 | 3.81 |
| 347.34 | 3.81 | 3.81 |
| 310.37 | 3.92 | 3.92 |
| 359.35 | 4.01 | 4.01 |
| 322.34 | 3.89 | 3.89 |
| 293.37 | 3.10 | 3.10 |
| 359.35 | 4.00 | 4.00 |
| 348.33 | 3.21 | 3.21 |
| 359.35 | 3.95 | 3.95 |
| 307.33 | 4.19 | 4.19 |
| 333.84 | 3.81 | 3.81 |
| 299.40 | 3.16 | 3.16 |
| 353.37 | 3.87 | 3.87 |
| 294.37 | 4.95 | 4.95 |
| 317.37 | 4.59 | 4.59 |
| 347.34 | 3.87 | 3.87 |
| 337.40 | 3.77 | 3.77 |
| 347.34 | 3.81 | 3.81 |
| 299.40 | 3.16 | 3.16 |
| 351.43 | 4.16 | 4.16 |
| 322.34 | 3.89 | 3.89 |
| 315.32 | 3.07 | 3.07 |
| 331.78 | 3.58 | 3.58 |