Basic Information
ID: ALA4340783
Type: Binding
Description: Inhibition of recombinant human BACE1 at 20 uM preincubated with enzyme for 20 mins followed by addition of Rh-EVNLDAEFK-Quencher as substrate measured after 60 mins by FRET assay relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: Beta-secretase 1(ALA4822)
Document: ALA4340508
Inhibition of recombinant human BACE1 at 20 uM preincubated with enzyme for 20 mins followed by addition of Rh-EVNLDAEFK-Quencher as substrate measured after 60 mins by FRET assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4340783
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 409.42 | 1.42 | 1.42 |
| 355.44 | 4.80 | 4.80 |
| 343.41 | 4.93 | 4.93 |
| 382.51 | 5.49 | 5.49 |
| 377.85 | 5.59 | 5.59 |
| 359.86 | 5.45 | 5.45 |
| 342.40 | 3.89 | 3.89 |
| 393.41 | 5.81 | 5.81 |
| 356.43 | 4.20 | 4.20 |
| 325.42 | 4.79 | 4.79 |
| 394.31 | 6.10 | 6.10 |
| 326.40 | 4.19 | 4.19 |
| 385.47 | 4.81 | 4.81 |
| 386.46 | 4.20 | 4.20 |
| 362.38 | 4.47 | 4.47 |
| 360.85 | 4.84 | 4.84 |
| 344.39 | 4.33 | 4.33 |
| 410.40 | 5.09 | 5.09 |
| 339.44 | 5.10 | 5.10 |
| 341.41 | 4.50 | 4.50 |
| 340.43 | 4.37 | 4.37 |
| 362.38 | 4.47 | 4.47 |
| 394.40 | 5.21 | 5.21 |