Basic Information
ID: ALA4341304
Type: Binding
Description: Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf9
Target: DNA topoisomerase I(ALA1781)
Document: ALA4340526
Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4341304
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 348.36 | 2.08 | 2.08 |
| 421.45 | 1.85 | 1.85 |
| 430.51 | 4.79 | 4.79 |
| 456.51 | 4.67 | 4.67 |
| 475.55 | 4.02 | 4.02 |
| 426.48 | 4.66 | 4.66 |
| 426.48 | 4.66 | 4.66 |
| 431.50 | 3.70 | 3.70 |
| 410.48 | 4.96 | 4.96 |
| 412.45 | 4.36 | 4.36 |
| 445.52 | 4.09 | 4.09 |
| 429.52 | 4.39 | 4.39 |
| 460.53 | 4.79 | 4.79 |
| 414.44 | 4.79 | 4.79 |
| 426.48 | 4.66 | 4.66 |
| 421.46 | 4.52 | 4.52 |
| 440.51 | 4.97 | 4.97 |
| 440.51 | 4.97 | 4.97 |
| 332.36 | 4.00 | 4.00 |
| 440.51 | 4.97 | 4.97 |
| 412.45 | 4.27 | 4.27 |
| 441.50 | 4.24 | 4.24 |
| 461.52 | 3.71 | 3.71 |
| 475.55 | 4.10 | 4.10 |
| 445.52 | 4.01 | 4.01 |
| 396.45 | 4.65 | 4.65 |
| 456.51 | 4.67 | 4.67 |