Basic Information
ID: ALA4341885
Type: Binding
Description: Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP stimulation and measured after 30 mins by sandwich ELISA
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4341885
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 425.88 | 4.99 | 4.99 |
| 441.88 | 4.11 | 4.11 |
| 445.01 | 3.70 | 3.70 |
| 460.02 | 4.16 | 4.16 |
| 425.88 | 4.99 | 4.99 |
| 451.95 | 4.65 | 4.65 |
| 397.85 | 3.85 | 3.85 |
| 466.96 | 3.60 | 3.60 |
| 450.96 | 4.58 | 4.58 |
| 194.08 | ||
| 411.88 | 4.50 | 4.50 |
| 338.79 | 4.44 | 4.44 |
| 425.88 | 4.99 | 4.99 |
| 419.93 | 4.11 | 4.11 |
| 441.88 | 4.11 | 4.11 |
| 412.86 | 4.47 | 4.47 |
| 407.89 | 5.04 | 5.04 |
| 404.89 | 6.01 | 6.01 |
| 450.96 | 4.58 | 4.58 |
| 406.90 | 6.10 | 6.10 |