In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 1.25 mg/kg, po measured at 8 hrs post dose relati...

Basic Information

ID: ALA4342650

Type: Functional

Description: In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 1.25 mg/kg, po measured at 8 hrs post dose relative to baseline

Format: BAO_0000218

Organism: Canis lupus familiaris

Strain: Beagle

Target: Canis familiaris(ALA373)

Document: ALA4342403

In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 1.25 mg/kg, po measured at 8 hrs post dose relative to baseline: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4342650

Inhibition

Total(2)

Parent Molecular Weight	ALogP	Polar Surface Area
432.46	2.87	2.87
484.50	2.90	2.90

Parent Molecular Weight

ALogP

Polar Surface Area

432.46

2.87

484.50

2.90

In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 1.25 mg/kg, po measured at 8 hrs post dose relati...

Basic Information

Activity Charts

Compound Summary