Basic Information
ID: ALA4345469
Type: Functional
Description: In vivo inhibition of TNSK/TNSK2-medited WNT/beta-catenin signaling in human COLO320DM cells xenografted Prkdc-NOD-SCID CB17 mouse assessed as reduction in total beta catenin expression in tumor nuclear extract at 10 to 20 mg/kg, po administered twice daily for 5 days followed by 2 days interval for 2 cycles measured 4 hrs post-last dose by Western blot analysis
Organism: Mus musculus
Strain: CB17
Activity Charts
Bioactivity
Activity Types for Assay ALA4345469
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 510.61 | 2.42 | 2.42 |