Basic Information
ID: ALA4345875
Type: Binding
Description: Inverse agonist activity at recombinant human GAL4-fused RORgammat LBD (247 to 497 residues) transfected in HEK293T cells assessed as inhibition of RORgammat driven transcriptional activity incubated for 24 hrs by dual-luciferase reporter gene assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Nuclear receptor ROR-gamma(ALA1741186)
Document: ALA4342512
Inverse agonist activity at recombinant human GAL4-fused RORgammat LBD (247 to 497 residues) transfected in HEK293T cells assessed as inhibition of RORgammat driven transcriptional activity incubated for 24 hrs by dual-luciferase reporter gene assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4345875
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 489.62 | 3.52 | 3.52 |
| 452.57 | 4.31 | 4.31 |
| 511.58 | 3.46 | 3.46 |
| 483.58 | 3.34 | 3.34 |
| 489.62 | 3.52 | 3.52 |
| 449.56 | 2.68 | 2.68 |
| 572.51 | 4.88 | 4.88 |
| 491.60 | 2.45 | 2.45 |
| 503.53 | 3.37 | 3.37 |
| 572.51 | 4.88 | 4.88 |
| 463.59 | 3.07 | 3.07 |
| 475.60 | 3.22 | 3.22 |
| 571.53 | 4.16 | 4.16 |
| 475.60 | 3.22 | 3.22 |