Basic Information
ID: ALA4346049
Type: Binding
Description: Inhibition of recombinant human GST-tagged p300 HAT domain (1195 to 1673 residues) expressed in Escherichia coli BL21 codon plus cells using Histone H3 peptide (1 to 21) and [3H]acetyl-CoA as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 30 mins by scintillation counting method
Format: BAO_0000219
Organism: Homo sapiens
Target: Histone acetyltransferase p300(ALA3784)
Document: ALA4342520
Inhibition of recombinant human GST-tagged p300 HAT domain (1195 to 1673 residues) expressed in Escherichia coli BL21 codon plus cells using Histone H3 peptide (1 to 21) and [3H]acetyl-CoA as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 30 mins by scintillation counting method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4346049
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 514.74 | 8.51 | 8.51 |
| 539.75 | 7.06 | 7.06 |
| 446.70 | 7.08 | 7.08 |
| 447.69 | 7.51 | 7.51 |
| 447.69 | 5.93 | 5.93 |
| 420.63 | 4.09 | 4.09 |
| 460.73 | 7.52 | 7.52 |
| 489.73 | 6.80 | 6.80 |
| 478.59 | 7.22 | 7.22 |
| 488.74 | 7.41 | 7.41 |
| 553.65 | 8.53 | 8.53 |
| 342.46 | 4.36 | 4.36 |
| 475.74 | 8.19 | 8.19 |
| 422.59 | 5.70 | 5.70 |
| 574.79 | 8.52 | 8.52 |
| 488.79 | 8.11 | 8.11 |
| 474.76 | 7.77 | 7.77 |
| 446.70 | 7.42 | 7.42 |
| 494.66 | 7.69 | 7.69 |
| 433.62 | 5.50 | 5.50 |
| 458.69 | 7.30 | 7.30 |
| 434.69 | 7.12 | 7.12 |
| 474.76 | 7.86 | 7.86 |
| 488.79 | 8.16 | 8.16 |
| 525.76 | 7.42 | 7.42 |
| 475.75 | 7.16 | 7.16 |
| 482.65 | 5.21 | 5.21 |
| 476.77 | 8.29 | 8.29 |
| 588.77 | 8.16 | 8.16 |
| 508.64 | 7.33 | 7.33 |
| 422.59 | 4.16 | 4.16 |
| 530.78 | 5.51 | 5.51 |
| 447.69 | 5.93 | 5.93 |
| 461.68 | 5.57 | 5.57 |
| 498.69 | 7.37 | 7.37 |
| 502.77 | 7.64 | 7.64 |
| 484.71 | 7.73 | 7.73 |