Basic Information
ID: ALA4346052
Type: Binding
Description: Potency index, ratio of IC50 of 4,5-Bis(4-(tert-butyl)phenyl)-N-(piperidin-4-ylmethyl)thiophene-2-carboxamide to IC50 of compund for inhibition of recombinant human GST-tagged p300 HAT domain (1195 to 1673 residues) expressed in Escherichia coli BL21 codon plus cells using Histone H3 (1 to 21) peptide and [3H]acetyl-CoA as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 30 mins by scintillation counting method
Format: BAO_0000219
Organism: Homo sapiens
Target: Histone acetyltransferase p300(ALA3784)
Document: ALA4342520
Potency index, ratio of IC50 of 4,5-Bis(4-(tert-butyl)phenyl)-N-(piperidin-4-ylmethyl)thiophene-2-carboxamide to IC50 of compund for inhibition of recombinant human GST-tagged p300 HAT domain (1195 to 1673 residues) expressed in Escherichia coli BL21 codon plus cells using Histone H3 (1 to 21) peptide and [3H]acetyl-CoA as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 30 mins by scintillation counting method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4346052
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 474.76 | 7.77 | 7.77 |