Assay Report Card

Basic Information

ID: ALA4346404

Type: Functional

Description: Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-induced intracellular calcium level measured for 100 secs by fluo-4 dye based FLIPR assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4346404

IC50

Total(56)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
338.41	3.50	3.50
425.45	1.96	1.96
354.37	2.56	2.56
381.39	2.21	2.21
322.32	2.34	2.34
326.36	2.80	2.80
390.40	2.38	2.38
371.44	2.89	2.89
422.45	1.86	1.86
297.32	2.18	2.18
409.45	2.99	2.99
310.36	2.72	2.72
326.36	2.80	2.80
359.39	1.48	1.48
297.32	2.18	2.18
308.34	2.70	2.70
314.35	1.83	1.83
366.38	1.90	1.90
411.42	1.57	1.57
297.32	2.18	2.18
340.34	2.52	2.52
324.38	3.11	3.11
356.38	2.81	2.81
381.39	2.21	2.21
296.33	2.79	2.79
423.43	2.29	2.29
275.27	0.59	0.59
365.39	2.51	2.51
395.42	2.60	2.60
409.40	2.20	2.20
326.36	2.80	2.80
384.40	2.11	2.11
356.38	2.81	2.81
381.39	2.21	2.21
395.42	2.00	2.00
407.43	2.74	2.74
379.42	2.81	2.81
383.38	2.64	2.64
421.46	3.13	3.13
337.34	2.93	2.93
395.42	2.51	2.51
395.42	2.60	2.60
311.35	3.18	3.18
327.34	2.19	2.19
357.44	3.30	3.30
335.37	3.27	3.27
327.34	2.19	2.19
332.39	2.34	2.34
312.33	2.49	2.49
379.38	2.03	2.03
383.41	1.55	1.55
325.37	2.86	2.86
351.41	2.98	2.98
312.33	2.49	2.49
327.34	2.19	2.19
312.33	2.49	2.49