Basic Information
ID: ALA4346904
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes assessed as reduction in metabolite formation using midazolam as substrate incubated for 10 mins in presence of NADPH by HPLC based mass spectrometric method
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 3A4(ALA340)
Document: ALA4346654
Inhibition of CYP3A4 in human liver microsomes assessed as reduction in metabolite formation using midazolam as substrate incubated for 10 mins in presence of NADPH by HPLC based mass spectrometric method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4346904
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 531.44 | 4.21 | 4.21 |
| 812.02 | 4.93 | 4.93 |
| 901.04 | 4.95 | 4.95 |
| 913.05 | 5.26 | 5.26 |
| 899.02 | 4.29 | 4.29 |