Basic Information
ID: ALA4347283
Type: Binding
Description: Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in calcium influx at 3 uM incubated for 10 mins prior to WS5 challenge by Fluo-4-AM dye based fluorescence assay relative to WS5
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Transient receptor potential cation channel subfamily M member 8(ALA1075319)
Document: ALA4346663
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in calcium influx at 3 uM incubated for 10 mins prior to WS5 challenge by Fluo-4-AM dye based fluorescence assay relative to WS5: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4347283
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 315.76 | 3.78 | 3.78 |
| 324.38 | 3.19 | 3.19 |
| 360.21 | 3.89 | 3.89 |
| 397.38 | 2.98 | 2.98 |
| 299.30 | 3.26 | 3.26 |
| 339.35 | 3.05 | 3.05 |
| 349.31 | 4.14 | 4.14 |
| 357.41 | 4.65 | 4.65 |
| 295.34 | 3.43 | 3.43 |
| 315.76 | 3.78 | 3.78 |
| 295.34 | 3.52 | 3.52 |
| 281.31 | 3.13 | 3.13 |