Basic Information
ID: ALA4348482
Type: Binding
Description: Potency index, ratio of IC50 for ceritinib to IC50 for test compound for inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as substrate incubated for 1 hr by mobility shift assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Proto-oncogene tyrosine-protein kinase ROS(ALA5568)
Document: ALA4346688
Potency index, ratio of IC50 for ceritinib to IC50 for test compound for inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as substrate incubated for 1 hr by mobility shift assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4348482
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 588.13 | 4.61 | 4.61 |