Basic Information
ID: ALA4348707
Type: Binding
Description: Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel electrophoresis method
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA topoisomerase I(ALA1781)
Document: ALA4346697
Inhibition of human topoisomerase 1 using supercoiled pBR322 plasmid DNA as substrate after 15 mins by ethidium bromide staining based agarose gel electrophoresis method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4348707
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 348.36 | 2.08 | 2.08 |
| 461.50 | 3.09 | 3.09 |
| 515.59 | 4.61 | 4.61 |
| 500.57 | 3.75 | 3.75 |
| 461.50 | 2.86 | 2.86 |
| 462.48 | 3.33 | 3.33 |
| 471.53 | 4.35 | 4.35 |
| 443.51 | 2.72 | 2.72 |
| 489.55 | 4.58 | 4.58 |
| 501.56 | 4.36 | 4.36 |
| 475.52 | 4.19 | 4.19 |
| 471.53 | 4.34 | 4.34 |
| 485.56 | 4.60 | 4.60 |
| 473.55 | 4.97 | 4.97 |
| 471.53 | 4.58 | 4.58 |
| 478.48 | 2.68 | 2.68 |
| 475.52 | 3.83 | 3.83 |
| 514.60 | 4.01 | 4.01 |
| 471.53 | 4.58 | 4.58 |
| 516.57 | 3.77 | 3.77 |
| 459.53 | 2.52 | 2.52 |
| 445.49 | 4.19 | 4.19 |
| 487.53 | 4.10 | 4.10 |
| 473.51 | 2.73 | 2.73 |
| 431.47 | 3.92 | 3.92 |
| 515.54 | 3.87 | 3.87 |
| 461.50 | 3.09 | 3.09 |
| 475.52 | 3.12 | 3.12 |
| 491.52 | 2.87 | 2.87 |
| 459.52 | 4.58 | 4.58 |
| 502.54 | 4.38 | 4.38 |
| 457.51 | 4.09 | 4.09 |
| 483.54 | 4.21 | 4.21 |
| 487.54 | 3.12 | 3.12 |
| 464.46 | 2.12 | 2.12 |
| 501.56 | 4.35 | 4.35 |
| 461.49 | 3.93 | 3.93 |
| 492.51 | 3.34 | 3.34 |
| 497.57 | 4.60 | 4.60 |
| 503.57 | 4.97 | 4.97 |
| 453.54 | 4.20 | 4.20 |
| 519.55 | 4.49 | 4.49 |
| 505.52 | 4.24 | 4.24 |
| 515.59 | 4.44 | 4.44 |
| 489.52 | 4.48 | 4.48 |