Basic Information
ID: ALA4349137
Type: Binding
Description: Irreversible inhibition of 1-(4-((2-((4-(4-(but-3-yn-1-yl)piperazin-1-yl)phenyl)amino)-5-(6-(methylamino)pyrazin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl)oxy)piperidin-1-yl)prop-2-en-1-one probe binding to recombinant human ITK at 20 uM preincubated for 2 hrs followed by probe addition and measured after 3 hrs by TAMRA azide-based fluorescence assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Tyrosine-protein kinase ITK/TSK(ALA2959)
Document: ALA4346710
Irreversible inhibition of 1-(4-((2-((4-(4-(but-3-yn-1-yl)piperazin-1-yl)phenyl)amino)-5-(6-(methylamino)pyrazin-2-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl)oxy)piperidin-1-yl)prop-2-en-1-one probe binding to recombinant human ITK at 20 uM preincubated for 2 hrs followed by probe addition and measured after 3 hrs by TAMRA azide-based fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4349137
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 555.64 | 3.59 | 3.59 |
| 555.64 | 3.59 | 3.59 |
| 543.68 | 5.41 | 5.41 |