ID: ALA4349922
Type: ADME
Description: Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Bioactivity
Activity Types for Assay ALA4349922
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
532.37 | 6.53 | 6.53 |
429.23 | 5.40 | 5.40 |
428.25 | 6.01 | 6.01 |
444.70 | 6.52 | 6.52 |
428.25 | 6.01 | 6.01 |
375.81 | 5.21 | 5.21 |
411.24 | 5.26 | 5.26 |
425.82 | 5.80 | 5.80 |
428.25 | 6.01 | 6.01 |
411.79 | 5.49 | 5.49 |
446.24 | 6.14 | 6.14 |
426.26 | 5.57 | 5.57 |
410.26 | 5.87 | 5.87 |
446.24 | 6.14 | 6.14 |
444.70 | 6.52 | 6.52 |
444.70 | 6.52 | 6.52 |
411.24 | 5.26 | 5.26 |
478.25 | 6.89 | 6.89 |
407.83 | 5.66 | 5.66 |
424.28 | 6.17 | 6.17 |
411.24 | 5.26 | 5.26 |
393.80 | 5.35 | 5.35 |
389.84 | 5.52 | 5.52 |
444.80 | 5.63 | 5.63 |
443.81 | 6.23 | 6.23 |
424.28 | 6.17 | 6.17 |
428.25 | 6.01 | 6.01 |
479.15 | 7.17 | 7.17 |
440.28 | 5.88 | 5.88 |
407.83 | 5.66 | 5.66 |
462.79 | 5.77 | 5.77 |
407.83 | 5.66 | 5.66 |
446.24 | 6.14 | 6.14 |
461.80 | 6.37 | 6.37 |
428.25 | 6.01 | 6.01 |
478.25 | 6.89 | 6.89 |
377.35 | 4.84 | 4.84 |
461.80 | 6.37 | 6.37 |
479.79 | 6.51 | 6.51 |
428.25 | 6.01 | 6.01 |
407.83 | 5.66 | 5.66 |
446.24 | 6.14 | 6.14 |
424.28 | 6.17 | 6.17 |
408.82 | 5.06 | 5.06 |