Basic Information
ID: ALA4351184
Type: Binding
Description: Inhibition of ABCB1 in human A2780/ADR cells at 10 uM preincubated for 30 mins followed by calcein AM addition and measured at 60 secs time interval by fluorescence assay relative to cyclosporine A
Format: BAO_0000219
Organism: Homo sapiens
Target: P-glycoprotein 1(ALA4302)
Document: ALA4350954
Inhibition of ABCB1 in human A2780/ADR cells at 10 uM preincubated for 30 mins followed by calcein AM addition and measured at 60 secs time interval by fluorescence assay relative to cyclosporine A: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4351184
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 461.51 | 3.61 | 3.61 |
| 419.51 | 3.44 | 3.44 |
| 408.53 | 2.41 | 2.41 |
| 454.53 | 3.25 | 3.25 |
| 423.97 | 4.83 | 4.83 |
| 498.66 | 4.23 | 4.23 |
| 494.64 | 5.20 | 5.20 |
| 397.48 | 4.00 | 4.00 |
| 414.53 | 4.32 | 4.32 |
| 484.63 | 4.07 | 4.07 |