Basic Information
ID: ALA4352155
Type: Binding
Description: Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2''3'']indolizino[8'',7'':5',6']pyrano[3',2':3,4]pyrido-[1,2-a]indol-5-ium-2-sulfonate binding to human GST/His-tagged RIP1 (1 to 375) expressed in baculovirus expression system preincubated for 10 mins followed by fluorescently labeled ATP-competitive ligand addition and measured after 20 mins by fluorescence polarization assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Receptor-interacting serine/threonine-protein kinase 1(ALA5464)
Document: ALA4350963
Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2''3'']indolizino[8'',7'':5',6']pyrano[3',2':3,4]pyrido-[1,2-a]indol-5-ium-2-sulfonate binding to human GST/His-tagged RIP1 (1 to 375) expressed in baculovirus expression system preincubated for 10 mins followed by fluorescently labeled ATP-competitive ligand addition and measured after 20 mins by fluorescence polarization assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4352155
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 299.76 | 4.30 | 4.30 |
| 228.29 | 2.75 | 2.75 |
| 244.34 | 3.30 | 3.30 |
| 308.40 | 2.40 | 2.40 |
| 245.33 | 1.93 | 1.93 |
| 244.34 | 3.24 | 3.24 |
| 249.33 | 3.54 | 3.54 |
| 221.26 | 1.98 | 1.98 |
| 230.31 | 2.99 | 2.99 |
| 335.41 | 2.65 | 2.65 |
| 231.30 | 2.39 | 2.39 |
| 220.28 | 1.72 | 1.72 |
| 230.31 | 2.99 | 2.99 |
| 220.28 | 1.72 | 1.72 |
| 231.30 | 2.39 | 2.39 |
| 367.49 | 3.76 | 3.76 |
| 396.40 | 2.80 | 2.80 |
| 246.31 | 1.96 | 1.96 |
| 251.29 | 2.65 | 2.65 |
| 251.37 | 1.96 | 1.96 |
| 334.42 | 3.26 | 3.26 |
| 339.40 | 2.55 | 2.55 |
| 335.41 | 2.65 | 2.65 |
| 249.38 | 3.31 | 3.31 |
| 242.32 | 3.14 | 3.14 |
| 246.35 | 2.21 | 2.21 |
| 353.34 | 2.75 | 2.75 |
| 228.29 | 3.24 | 3.24 |
| 247.34 | 2.63 | 2.63 |
| 352.40 | 1.62 | 1.62 |
| 222.33 | 2.81 | 2.81 |
| 256.35 | 3.53 | 3.53 |
| 238.33 | 2.05 | 2.05 |
| 258.32 | 2.37 | 2.37 |
| 299.37 | 2.20 | 2.20 |
| 244.29 | 1.98 | 1.98 |
| 262.33 | 3.44 | 3.44 |
| 396.40 | 2.80 | 2.80 |
| 216.28 | 2.60 | 2.60 |
| 251.29 | 2.65 | 2.65 |
| 230.31 | 2.99 | 2.99 |
| 351.41 | 2.22 | 2.22 |
| 313.40 | 2.59 | 2.59 |
| 271.36 | 2.29 | 2.29 |
| 286.42 | 4.29 | 4.29 |
| 248.30 | 3.13 | 3.13 |
| 217.31 | 3.01 | 3.01 |
| 396.40 | 2.80 | 2.80 |
| 231.30 | 2.39 | 2.39 |
| 244.34 | 3.38 | 3.38 |
| 375.38 | 2.83 | 2.83 |
| 362.43 | 2.89 | 2.89 |
| 352.39 | 2.49 | 2.49 |
| 368.46 | 2.95 | 2.95 |
| 299.37 | 2.20 | 2.20 |
| 251.29 | 2.65 | 2.65 |
| 260.38 | 2.55 | 2.55 |
| 264.76 | 3.65 | 3.65 |
| 335.41 | 2.65 | 2.65 |
| 396.40 | 2.80 | 2.80 |
| 250.30 | 3.26 | 3.26 |
| 333.44 | 3.86 | 3.86 |
| 362.43 | 2.89 | 2.89 |
| 264.76 | 3.65 | 3.65 |
| 245.37 | 3.79 | 3.79 |
| 351.41 | 2.22 | 2.22 |
| 231.34 | 3.40 | 3.40 |
| 352.39 | 2.49 | 2.49 |
| 361.45 | 3.50 | 3.50 |
| 236.36 | 3.20 | 3.20 |
| 266.29 | 3.27 | 3.27 |
| 333.44 | 3.86 | 3.86 |