Basic Information
ID: ALA4353457
Type: Binding
Description: Protac activity at CRBN/MDM2 in human RS4:11 cells assessed as reduction in MDM2 degradation at 100 nM preincubated with ((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazol-1-yl)(piperazin-1-yl)methanone for 2 hrs followed by compound addition measured after 4 hrs by Western blot analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4353457
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 859.85 | 7.78 | 7.78 |