Assay Report Card

Basic Information

ID: ALA4353688

Type: Binding

Description: Inhibition of N-terminal His-tagged recombinant human KDM4A (1 to 359 residues) expressed in Escherichia coli assessed as decrease in demethylation of substrate using peptide (ARTKQTARK(Me3)STGGKAPRKQLA-GGKbiotin) as substrate and 2OG as cosubstrate pre-incubated for 10 mins before substrate addition followed by centrifugation for 1 min and measured after 20 mins by AlphaScreen assay

Organism: Homo sapiens

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
454.583.643.64
478.563.383.38
471.613.033.03
513.652.802.80
352.442.342.34
418.483.073.07
426.523.033.03
338.422.092.09
428.502.572.57
513.652.802.80
472.593.963.96
442.574.054.05
310.361.311.31
390.451.621.62
551.624.544.54
456.594.224.22
483.583.053.05
364.452.482.48
364.452.632.63
350.432.092.09
430.512.932.93
499.622.762.76
581.643.823.82
478.563.383.38
477.573.993.99
324.391.701.70
477.573.993.99
477.573.993.99
477.573.993.99
448.963.753.75
471.613.033.03
477.573.993.99
483.623.523.52