ID: ALA4353689
Type: Binding
Description: Inhibition of N-terminal GST-tagged recombinant human KDM4B (1 to 500 residues) expressed in baculovirus infected Sf9 insect cells assessed as decrease in demethylation of substrate using peptide (ARTKQTARK(Me3)STGGKAPRKQLA-GGKbiotin) as substrate and 2OG as cosubstrate pre-incubated for 10 mins before substrate addition followed by centrifugation for 1 min and measured after 20 mins by AlphaScreen assay
Organism: Homo sapiens
Cell type: Sf9
Bioactivity
Activity Types for Assay ALA4353689
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
454.58 | 3.64 | 3.64 |
478.56 | 3.38 | 3.38 |
471.61 | 3.03 | 3.03 |
513.65 | 2.80 | 2.80 |
352.44 | 2.34 | 2.34 |
418.48 | 3.07 | 3.07 |
426.52 | 3.03 | 3.03 |
338.42 | 2.09 | 2.09 |
428.50 | 2.57 | 2.57 |
513.65 | 2.80 | 2.80 |
472.59 | 3.96 | 3.96 |
442.57 | 4.05 | 4.05 |
310.36 | 1.31 | 1.31 |
390.45 | 1.62 | 1.62 |
551.62 | 4.54 | 4.54 |
456.59 | 4.22 | 4.22 |
483.58 | 3.05 | 3.05 |
364.45 | 2.48 | 2.48 |
364.45 | 2.63 | 2.63 |
350.43 | 2.09 | 2.09 |
430.51 | 2.93 | 2.93 |
499.62 | 2.76 | 2.76 |
581.64 | 3.82 | 3.82 |
478.56 | 3.38 | 3.38 |
477.57 | 3.99 | 3.99 |
324.39 | 1.70 | 1.70 |
477.57 | 3.99 | 3.99 |
477.57 | 3.99 | 3.99 |
477.57 | 3.99 | 3.99 |
448.96 | 3.75 | 3.75 |
471.61 | 3.03 | 3.03 |
477.57 | 3.99 | 3.99 |
483.62 | 3.52 | 3.52 |