Basic Information
ID: ALA4353713
Type: Binding
Description: Inhibition of full length human KDM4B assessed as decrease in demethylation of substrate using peptide (ARTKQTARK(Me3)STGGKAPRKQLA-GGKbiotin) as substrate and 8 uM 2OG as cosubstrate pre-incubated for 10 mins before substrate addition followed by centrifugation for 1 min and measured after 15 mins by AlphaScreen assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Lysine-specific demethylase 4B(ALA3313832)
Document: ALA4350996
Inhibition of full length human KDM4B assessed as decrease in demethylation of substrate using peptide (ARTKQTARK(Me3)STGGKAPRKQLA-GGKbiotin) as substrate and 8 uM 2OG as cosubstrate pre-incubated for 10 mins before substrate addition followed by centrifugation for 1 min and measured after 15 mins by AlphaScreen assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4353713
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 471.61 | 3.03 | 3.03 |
| 426.52 | 3.03 | 3.03 |
| 364.45 | 2.48 | 2.48 |