Basic Information
ID: ALA4354244
Type: Binding
Description: Inhibition of recombinant human N-terminal GST-tagged ROS1 (catalytic domain 1883 - 2347 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate preincubated with enzyme for 30 mins followed by substrate addition by HTRF method
Format: BAO_0000019
Organism: Homo sapiens
Target: Proto-oncogene tyrosine-protein kinase ROS(ALA5568)
Document: ALA4351011
Inhibition of recombinant human N-terminal GST-tagged ROS1 (catalytic domain 1883 - 2347 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate preincubated with enzyme for 30 mins followed by substrate addition by HTRF method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4354244
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 450.35 | 5.04 | 5.04 |
| 488.51 | 4.30 | 4.30 |
| 472.47 | 4.05 | 4.05 |
| 681.80 | 5.48 | 5.48 |
| 668.76 | 5.57 | 5.57 |
| 584.64 | 4.67 | 4.67 |
| 488.51 | 4.30 | 4.30 |
| 519.65 | 3.50 | 3.50 |
| 681.80 | 5.48 | 5.48 |
| 598.67 | 5.02 | 5.02 |
| 596.70 | 6.07 | 6.07 |
| 418.55 | 3.71 | 3.71 |
| 668.76 | 5.57 | 5.57 |
| 490.60 | 4.69 | 4.69 |
| 584.64 | 4.67 | 4.67 |
| 533.68 | 3.84 | 3.84 |
| 450.54 | 3.11 | 3.11 |
| 498.64 | 3.69 | 3.69 |
| 596.70 | 6.07 | 6.07 |
| 464.57 | 3.42 | 3.42 |