Basic Information
ID: ALA4354246
Type: Binding
Description: Inhibition of recombinant human N-terminal GST-tagged ALK (catalytic domain 1058 - 1620 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate at 1 uM preincubated with enzyme for 30 mins followed by substrate addition by HTRF method relative to control
Format: BAO_0000019
Organism: Homo sapiens
Target: ALK tyrosine kinase receptor(ALA4247)
Document: ALA4351011
Inhibition of recombinant human N-terminal GST-tagged ALK (catalytic domain 1058 - 1620 residues) expressed in baculovirus system assessed as decrease in substrate phosphorylation using TK peptide as substrate at 1 uM preincubated with enzyme for 30 mins followed by substrate addition by HTRF method relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4354246
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 450.35 | 5.04 | 5.04 |
| 488.51 | 4.30 | 4.30 |
| 472.47 | 4.05 | 4.05 |
| 681.80 | 5.48 | 5.48 |
| 668.76 | 5.57 | 5.57 |
| 584.64 | 4.67 | 4.67 |
| 488.51 | 4.30 | 4.30 |
| 519.65 | 3.50 | 3.50 |
| 681.80 | 5.48 | 5.48 |
| 598.67 | 5.02 | 5.02 |
| 596.70 | 6.07 | 6.07 |
| 418.55 | 3.71 | 3.71 |
| 668.76 | 5.57 | 5.57 |
| 490.60 | 4.69 | 4.69 |
| 584.64 | 4.67 | 4.67 |
| 533.68 | 3.84 | 3.84 |
| 450.54 | 3.11 | 3.11 |
| 498.64 | 3.69 | 3.69 |
| 596.70 | 6.07 | 6.07 |
| 464.57 | 3.42 | 3.42 |