Basic Information
ID: ALA4354684
Type: Binding
Description: Inhibition of RyR1 harboring R2163C mutant (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as suppression in Ca2+ leakage from ER prestimulated with doxycycline for 24 to 28 hrs followed by compound addition at 100 secs and measured every 10 secs for 300 secs by time lapse fluorimetry based Michelis-Menten analysis
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4354684
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 261.23 | 1.45 | 1.45 |
| 189.17 | 1.64 | 1.64 |
| 259.30 | 2.89 | 2.89 |
| 203.20 | 1.24 | 1.24 |
| 279.30 | 2.75 | 2.75 |
| 314.26 | 1.74 | 1.74 |
| 273.33 | 3.28 | 3.28 |
| 261.28 | 2.12 | 2.12 |
| 369.38 | 5.08 | 5.08 |
| 243.26 | 2.11 | 2.11 |
| 245.28 | 2.42 | 2.42 |
| 345.40 | 3.79 | 3.79 |
| 373.45 | 4.57 | 4.57 |
| 331.41 | 4.07 | 4.07 |
| 231.25 | 2.11 | 2.11 |
| 341.45 | 4.55 | 4.55 |
| 261.28 | 2.12 | 2.12 |
| 217.22 | 1.72 | 1.72 |
| 301.39 | 4.06 | 4.06 |
| 245.28 | 2.42 | 2.42 |
| 331.41 | 4.07 | 4.07 |
| 329.44 | 4.84 | 4.84 |
| 245.28 | 2.50 | 2.50 |
| 285.34 | 3.28 | 3.28 |
| 287.36 | 3.67 | 3.67 |
| 361.44 | 4.08 | 4.08 |
| 315.41 | 4.37 | 4.37 |
| 315.41 | 4.45 | 4.45 |
| 331.41 | 4.07 | 4.07 |
| 361.44 | 4.08 | 4.08 |
| 315.41 | 4.37 | 4.37 |
| 347.48 | 4.78 | 4.78 |
| 385.38 | 4.96 | 4.96 |