Basic Information
ID: ALA4354709
Type: Binding
Description: Reversal of ABCG2-mediated multidrug resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring inhibition of cell proliferation at 25 uM pretreated for 2 hrs followed by mitoxantrone addition and measured after 44 hrs by MTT assay (Rvb = 24 +/- 3%)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4354709
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 311.34 | 3.42 | 3.42 |
| 269.26 | 2.52 | 2.52 |
| 269.26 | 2.52 | 2.52 |
| 475.50 | 4.67 | 4.67 |
| 253.26 | 2.81 | 2.81 |
| 253.26 | 2.81 | 2.81 |
| 415.45 | 4.66 | 4.66 |
| 253.26 | 2.81 | 2.81 |
| 352.39 | 4.11 | 4.11 |
| 311.34 | 3.42 | 3.42 |