Basic Information
ID: ALA4355675
Type: Binding
Description: Selectivity index, ratio of IC50 for recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay to IC50 for recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Unchecked(ALA612545)
Document: ALA4354804
Selectivity index, ratio of IC50 for recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay to IC50 for recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4355675
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 302.37 | 2.58 | 2.58 |
| 446.50 | 3.87 | 3.87 |
| 341.41 | 3.64 | 3.64 |
| 452.47 | 3.74 | 3.74 |
| 339.18 | 3.04 | 3.04 |
| 344.15 | 2.07 | 2.07 |
| 331.15 | 3.11 | 3.11 |
| 377.87 | 3.96 | 3.96 |
| 351.36 | 2.43 | 2.43 |
| 358.38 | 2.49 | 2.49 |
| 446.33 | 5.36 | 5.36 |
| 316.79 | 3.41 | 3.41 |
| 349.82 | 3.22 | 3.22 |
| 457.44 | 2.77 | 2.77 |
| 325.32 | 1.92 | 1.92 |
| 368.22 | 4.08 | 4.08 |
| 275.26 | 0.77 | 0.77 |
| 329.18 | 3.67 | 3.67 |