Basic Information
ID: ALA4356096
Type: Binding
Description: Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing five copies of HREs and pRL-SV40 plasmid encoding Renilla luciferase at 10 uM incubated with compound under normoxia for 1 hr followed by hypoxia induction and measured after 24 hrs by HRE-dependent dual luciferase reporter gene assay relative to control
Format: BAO_0000019
Organism: Homo sapiens
Target: Hypoxia-inducible factor 1 alpha(ALA4261)
Document: ALA4354811
Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing five copies of HREs and pRL-SV40 plasmid encoding Renilla luciferase at 10 uM incubated with compound under normoxia for 1 hr followed by hypoxia induction and measured after 24 hrs by HRE-dependent dual luciferase reporter gene assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4356096
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 435.52 | 4.66 | 4.66 |
| 240.31 | 2.36 | 2.36 |
| 303.37 | 3.12 | 3.12 |
| 263.72 | 3.21 | 3.21 |
| 247.32 | 1.82 | 1.82 |
| 302.38 | 3.72 | 3.72 |
| 246.34 | 2.42 | 2.42 |
| 247.32 | 1.82 | 1.82 |
| 293.33 | 2.71 | 2.71 |
| 273.76 | 3.62 | 3.62 |
| 318.38 | 3.43 | 3.43 |
| 336.37 | 3.57 | 3.57 |
| 320.37 | 3.86 | 3.86 |
| 350.39 | 3.87 | 3.87 |
| 302.38 | 3.72 | 3.72 |
| 316.40 | 4.03 | 4.03 |
| 247.32 | 1.82 | 1.82 |
| 321.36 | 3.26 | 3.26 |
| 350.39 | 3.87 | 3.87 |
| 336.37 | 3.57 | 3.57 |
| 317.39 | 3.30 | 3.30 |
| 274.75 | 3.02 | 3.02 |
| 335.83 | 4.98 | 4.98 |
| 326.78 | 3.97 | 3.97 |
| 310.33 | 3.45 | 3.45 |
| 350.39 | 3.87 | 3.87 |
| 320.37 | 3.86 | 3.86 |
| 343.84 | 3.83 | 3.83 |
| 260.36 | 2.81 | 2.81 |
| 310.33 | 3.45 | 3.45 |
| 326.40 | 3.92 | 3.92 |
| 280.78 | 3.08 | 3.08 |
| 327.77 | 3.36 | 3.36 |
| 304.35 | 2.51 | 2.51 |
| 303.37 | 3.12 | 3.12 |
| 294.31 | 2.10 | 2.10 |
| 337.81 | 3.77 | 3.77 |
| 326.40 | 3.92 | 3.92 |
| 345.38 | 3.73 | 3.73 |
| 326.78 | 3.97 | 3.97 |
| 294.31 | 2.10 | 2.10 |
| 241.29 | 1.76 | 1.76 |
| 280.78 | 3.08 | 3.08 |
| 336.82 | 4.37 | 4.37 |
| 336.82 | 4.37 | 4.37 |
| 343.84 | 3.83 | 3.83 |
| 310.38 | 2.57 | 2.57 |
| 345.38 | 3.73 | 3.73 |
| 342.85 | 4.44 | 4.44 |
| 303.37 | 3.12 | 3.12 |
| 336.82 | 4.37 | 4.37 |
| 347.37 | 3.63 | 3.63 |
| 327.77 | 3.36 | 3.36 |
| 336.37 | 3.57 | 3.57 |
| 293.33 | 2.71 | 2.71 |
| 280.78 | 3.08 | 3.08 |
| 320.37 | 3.86 | 3.86 |
| 309.39 | 3.18 | 3.18 |
| 230.27 | 1.96 | 1.96 |
| 345.38 | 3.73 | 3.73 |
| 338.36 | 4.00 | 4.00 |
| 310.33 | 2.58 | 2.58 |
| 338.36 | 4.00 | 4.00 |
| 338.36 | 4.00 | 4.00 |
| 327.77 | 3.36 | 3.36 |
| 294.31 | 2.10 | 2.10 |
| 303.37 | 3.12 | 3.12 |
| 336.82 | 4.37 | 4.37 |
| 310.38 | 2.57 | 2.57 |
| 232.31 | 2.38 | 2.38 |