Basic Information
ID: ALA4356100
Type: Binding
Description: Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing five copies of HREs and pRL-SV40 plasmid encoding Renilla luciferase incubated with compound under normoxia for 1 hr followed by hypoxia induction and measured after 24 hrs by HRE-dependent dual luciferase reporter gene assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Hypoxia-inducible factor 1 alpha(ALA4261)
Document: ALA4354811
Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing five copies of HREs and pRL-SV40 plasmid encoding Renilla luciferase incubated with compound under normoxia for 1 hr followed by hypoxia induction and measured after 24 hrs by HRE-dependent dual luciferase reporter gene assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4356100
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 435.52 | 4.66 | 4.66 |
| 302.38 | 3.72 | 3.72 |
| 246.34 | 2.42 | 2.42 |
| 350.39 | 3.87 | 3.87 |
| 317.39 | 3.30 | 3.30 |
| 335.83 | 4.98 | 4.98 |
| 310.33 | 3.45 | 3.45 |
| 326.40 | 3.92 | 3.92 |
| 304.35 | 2.51 | 2.51 |
| 303.37 | 3.12 | 3.12 |
| 326.40 | 3.92 | 3.92 |
| 336.82 | 4.37 | 4.37 |
| 336.82 | 4.37 | 4.37 |
| 345.38 | 3.73 | 3.73 |
| 320.37 | 3.86 | 3.86 |
| 338.36 | 4.00 | 4.00 |
| 294.31 | 2.10 | 2.10 |