Basic Information
ID: ALA4358489
Type: Binding
Description: Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by anti-IgM antibody/IL4 stimulation and measured after 16 hrs by flow cytometry
Format: BAO_0000219
Organism: Homo sapiens
Target: Tyrosine-protein kinase BTK(ALA5251)
Document: ALA4354855
Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by anti-IgM antibody/IL4 stimulation and measured after 16 hrs by flow cytometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4358489
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 440.51 | 4.22 | 4.22 |
| 465.52 | 3.31 | 3.31 |
| 454.49 | 2.75 | 2.75 |
| 429.52 | 4.35 | 4.35 |
| 370.43 | 2.13 | 2.13 |
| 519.55 | 4.30 | 4.30 |
| 521.57 | 4.86 | 4.86 |
| 564.64 | 4.40 | 4.40 |
| 533.58 | 5.00 | 5.00 |
| 499.59 | 5.35 | 5.35 |
| 492.53 | 4.16 | 4.16 |
| 541.53 | 3.71 | 3.71 |
| 487.54 | 4.08 | 4.08 |
| 533.58 | 5.00 | 5.00 |
| 509.56 | 4.69 | 4.69 |
| 505.53 | 3.91 | 3.91 |
| 507.54 | 4.47 | 4.47 |
| 523.54 | 3.57 | 3.57 |
| 533.58 | 5.00 | 5.00 |
| 503.55 | 5.10 | 5.10 |
| 521.57 | 4.86 | 4.86 |
| 493.51 | 4.12 | 4.12 |
| 485.56 | 4.96 | 4.96 |
| 505.53 | 4.22 | 4.22 |
| 521.57 | 4.86 | 4.86 |
| 519.55 | 4.61 | 4.61 |
| 501.56 | 4.47 | 4.47 |
| 519.55 | 4.61 | 4.61 |